PHARMACEUTICAL PLANT AREA MEETS GACP-WHO STANDARD

Crinum latifolium L. plantation with an area of 20 hectares in Long Thanh – Dong Nai established since 1994 has been cultivated, cared, collected and stored under GACP – WHO (Good Agriculture and Collection Practices – World Health Organization) criterion. As a result, Crinum latifolium L. materials achieve high and stable bioactive substances. Since 1990, we have chosen and selected Crinum latifolium L. varieties detected by Dr. Nguyen Thi Ngoc Tram based on specific genetic characteristics (ADN), botanical morphology, and chemical substances of Crinum latifolium L. Royal Virgin (Crinum latifolium L.) used as raw materials for producing Crila, Crila Forte, Crilin supplement and Crinum latifolium L. tea was published by Dr. Nguyen Thi Ngoc Tram and Prof. Dr. Sc. Tran Cong Khanh on Journal of Biology No. 2, Vol. 34 on June 2012 as a novel variety of Vietnamese Crinum latifolium species with its scientific name – “Crinum latifolium L.” (Crinum latifolium L. var. crilae Tram & Khanh) belonging to Amaryllidaceae family.

After selecting right Crinum latifolium L. varieties with bioactivity prohibiting the growth of tumor cells and stimulating the immune system used as raw materials for producing medicine, we chose Long Thanh – Dong Nai as a place for the development of Crinum latifolium L. materials. It was in this area that Dr. Tram found the Crinum latifolium L. having bioactivity for the treatment of tumors, so the soil property and climate here are suitable for the plant growth. The plantation has favorable location which is 1 km away from main roads, unpolluted with crowded residential areas, not near factories, enterprises, hospitals, and cemeteries, with suitable climate for the plant. The plantation uses water in accordance with national technical standards of running-water quality according to provision QCVN 01: 2009/BYT issued by the Ministry of Health. In cultivating process, no chemical fertilizers, growth stimulants and pesticides are accepted but using hands or pheromones – a synthetic substance with the same chemical structure as extract from female worm provided by Prof. Dr. Sc. Nguyen Cong Hao from Vietnam Institute of Sciences and Technology – to catch caterpillars by luring male caterpillars. This helps to prevent female ones from fertilizing and laying eggs. Weeding is done by our own designed machine. Crinum latifolium L. is collected when bioactive alkaloids from the leaves reach the highest content, then it is washed with water meeting national technical standards of running-water quality. In order to make sure that bioactive substances are not decomposed due to high temperature, we have established a drying process with appropriate temperature. Based on the appraisal results by experts from the Ministry of Health, on  October 13th, 2011 the Drug Administration – Ministry of Health certified Crinum latifolium L. plantation in Long Thanh – Dong Nai of Thien Duoc Co., Ltd under GACP – WHO (Good Agriculture and Collection Practices – World Health Organization) criterion. Now, our Crinum latifolium L. plantation is the first medicinal material plantation in Viet Nam under GACP-WHO.