Crilin T is created from the international cooperation mission in science and technology under the protocol between Vietnam and Bulgaria “Research of immunostimulative effect against cancer of alkaloids and flavonoids extracted from Vietnamese Crinum latifolium L. used as materials for producing medicines supporting cancer treatment” and the scientific research subject at the Ministry of Health level “Research of biological effects and safety of alkaloid and flavonoid fractions from Vietnamese Crinum latifolium L.” 

Pharmacist-Dr. Nguyen Thi Ngoc Tram – Director of Thien Duoc Co., Ltd is the manager of these two scientific research projects. She has received two utility solution patents No.1168 for “Selective extraction process of bioactive alkaloid fractions for cancer treatment from Crinum latifolium L. leaves” under the Decision No.19254/QĐ-SHTT and No.1213 for “Selective extraction process of bioactive flavonoid fractions supporting cancer treatment from Crinum latifolium L. leaves” under the Decision No. 70507/QĐ-SHTT. These two scientific research projects were accepted and evaluated at fair and excellent level, so Crilin T was suggested for clinical trials on lung and prostate cancer by the Council of Science and Technology – the Ministry of Health.

So far, cancer is still a serious disease challenging many scientists. Cancer treatment with surgery, chemotherapy and radiotherapy also has many undesirable effects and high treatment costs. So, the scientists are trying to develop herbal medicines for cancer treatment and cancer treatment support because new medicines for cancer treatment have many side effects and high costs compared to herbal medicines. That motivates the scientists continue to search and do research in natural herbs, animals, minerals, etc. to find new medicinal herbs to save people from the risk of cancer. Dr. Tram and her colleagues who are highly experienced scientists in and outside the country have tried to search from Vietnamese rich sources of herbs in which Crinum latifolium L. var. crilae Tram & Khanh - one of the valuable medicinal plants in Vietnam discovered, domesticated and cultivated by Dr. Tram, is a novel variety of Vietnamese Crinum latifolium L. Dr. Tram desires to produce a specific medicine for the treatment of lung and prostate cancer. She has studied this Vietnamese medicinal herb since 1990 and produced Crila® which treats benign prostatic hyperplasia (BPH) and uterine fibroids with high treatment efficacy and safety for patients. Moreover, in order to help patients prevent tumor diseases, Thien Duoc Co., Ltd as a technology-receiving unit of Dr. Tram’s research work has produced other products such as Crilin® and Crinum latifolium L. teabag to support tumor treatment. These two products contribute to the prevention of tumor diseases and against cancer relapse after surgery, radiotherapy and chemotherapy. Especially, these products are produced from clean material sources harvested and processed according to GACP-WHO (Good Agriculture and Collection Practice – World Health Organization) criteria on an area of 20ha in Long Thanh – Dong Nai, with stable bioactive content and at a GMP-WHO (Good Manufacturing Practice – World Health Organization) manufacturing factory. With its preeminence, Crila® has been officially allowed for circulation on the highly demanding U.S. market since 2011 by the U.S. FDA (Food and Drug Administration). Revenue of Crila® in and outside the country in recent years has also increased gradually.

In the coming time, Dr. Tram’s scientific research work will give birth to Crilin T which is a result of research work at state and ministry levels formulated from alkaloid and flavonoid fractions proven to have bioactive substances, antioxidative activity and immunoenhancing properties against tumors indirectly or cytotoxicity directly on cancer cell lines of liver, lung and prostate. Crilin T is created from technological innovation in cultivation, extraction and formulation, so it is safe for patients and has high treatment efficacy which will be highly welcomed by patients and help bring Vietnamese drug brand to a higher level on the international pharmaceutical market.